In vitro study of the antimitotic power and in vivo acute toxicity of aqueous and organic extracts of the aerial part of Haloxylon scoparium Pomel. and evaluation of the correlation between the chemical profile and their biological activities

The present study was conducted on the extracts from aerial part of Haloxylon scoparium Pomel. current research has focused evaluation antimitotic activity with Lepidium sativum phytotest aqueous (decocted, infused, macerated) and organic (methanolic extract, methanolic macerated, ethyl acetate chloroform extract petroleum ether extract) portion scoparium. In order to visualise correlation between content chemical compounds in results phytotest, we have used principal component analysis (PCA). Then, were interested studying acute vivo toxicity decocted Antimitotic shown that exhibited high inhibition germination (IC50=128.16±3.89 µg/mL) than colchicine (IC50=474.66±1.86 µg/mL). also showed compared other (IC50=1359.00±106.69 there is a strong total polyphenol (r=0.9453) flavonoid (r=0.9884) composition. addition, MLD50 estimated at 2000 mg/kg. shows could be potential low toxicity.